🧬 Pinealon Peptide – Structure, Function & Research Applications;

Introduction

Pinealon peptide is a synthetic tripeptide complex that has become an important subject in neurochemical and biochemical research. Derived from naturally occurring short peptides, Pinealon is studied for its potential role in cellular protection, regulation of oxidative balance, and peptide-based signaling within neural and endocrine systems.

As a research-use-only (RUO) compound, Pinealon is not approved for medical or dietary use. Instead, it is applied in academic and laboratory studies focusing on peptide activity, metabolic regulation, and cellular biochemistry.

Chemical Identity and Structure

• Peptide Name: Pinealon

• Sequence: Glu-Asp-Arg

• Molecular Formula: C₁₂H₂₀N₆O₈

• Molecular Weight: 392.33 g/mol

• Peptide Type: Synthetic tripeptide analog

• Form: Lyophilized powder

• Purity: ≥ 98 % (HPLC verified)

The simplicity of Pinealon’s three-amino-acid sequence allows precise study of short-chain peptide interactions and cellular response mechanisms under laboratory conditions.

Scientific Background

Pinealon belongs to a class of short regulatory peptides developed through peptide bioregulation research. These peptides are designed to mimic fragments of natural regulatory proteins that influence gene expression, cell division, and metabolic balance.

In laboratory models, Pinealon has been used to explore:

• Oxidative-stress response at the cellular level

• Gene-expression modulation in neuronal cultures

• Cytoprotective activity against free-radical damage

• Neuropeptide signaling pathways related to brain metabolism

While findings remain experimental, Pinealon serves as an important model compound for studying small-molecule peptide biochemistry.

Mechanistic Research Focus

1. Antioxidant and Cellular Defense Studies

Pinealon’s structure allows researchers to evaluate how short peptides interact with reactive oxygen species and support cellular redox regulation in vitro.

2. Neurochemical Signaling

Experimental models use Pinealon to investigate neurotransmitter modulation and peptide-receptor communication within the central nervous system.

3. Peptide Biostability Research

Because it is a small, compact molecule, Pinealon provides insight into how tripeptides resist enzymatic breakdown and maintain activity during long-term experiments.

Applications in Scientific Research

Pinealon peptide is used across multiple research domains, including:

• Molecular biology – studying peptide-gene interaction and transcriptional regulation

• Neuroscience – examining cellular stress responses and neuropeptide signaling

• Biochemistry – analyzing oxidative defense mechanisms and peptide stability

• Peptide engineering – exploring tripeptide design for bioactivity testing

Its minimalistic structure makes Pinealon an efficient model in short-peptide design and synthetic biopeptide analysis.

Storage and Handling

• Storage: −20 °C (lyophilized)

• Solubility: Water or buffer (pH 7.0–7.4)

• Shelf Life: 24 months if unopened and dry

• Reconstitution: Prepare fresh solution for each experiment

• Handling: Avoid repeated freeze–thaw cycles

• Usage: For research use only; not for human or veterinary applications

Regulatory and Safety Information

Pinealon peptide is not approved by the FDA, EMA, or TGA for therapeutic, dietary, or cosmetic use.
Distribution and labeling must clearly specify “for research use only (RUO)”.
Follow all local laboratory biosafety guidelines for peptide handling and disposal.

Conclusion

Pinealon peptide stands out as a versatile research compound for investigating short-chain peptides and their biological roles in cellular stability and oxidative regulation.
Its simple yet bioactive structure makes it an ideal model for studying how small peptides influence metabolic processes and molecular communication in neural and somatic cells.

While not intended for human use, It continues to serve as a key tool for advancing our understanding of peptide bioregulation and cellular homeostasis in modern biochemistry.